1 Identification of NIPSNAP 1 as a Nocistatin -
نویسندگان
چکیده
From Department of Medical Chemistry, Kansai Medical University, Moriguchi, Japan; Department of Biomedical Engineering, Osaka Institute of Technology, Osaka, Japan; Department of Anesthesiology, Osaka Medical College, Takatsuki, Japan; Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama, Japan; Laboratory for Animal Resources and Genetic Engineering, RIKEN Center for Developmental Biology, Kobe, Japan; Protein Research Network, Yokohama, Japan; Department of Cell Biology, Japanese Foundation for Cancer Research, Cancer Institute, Tokyo, Japan.
منابع مشابه
Involvement of NIPSNAP1, a neuropeptide nocistatin-interacting protein, in inflammatory pain
BACKGROUND Chronic pain associated with inflammation is an important clinical problem, and the underlying mechanisms remain poorly understood. 4-Nitrophenylphosphatase domain and nonneuronal SNAP25-like protein homolog (NIPSNAP) 1, an interacting protein with neuropeptide nocistatin, is implicated in the inhibition of tactile pain allodynia. Although nocistatin inhibits some inflammatory pain r...
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Nociceptin/orphanin FQ and nocistatin are two neuropeptides with opposing effects on spinal neurotransmission and nociception. Nociceptin/orphanin FQ selectively suppresses excitatory glutamatergic neurotransmission, while nocistatin selectively interferes with glycinergic and gamma-aminobutyric acid (GABA)-ergic transmission. Here, we performed whole-cell patch-clamp recordings from superficia...
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Nociceptin/orphanin FQ (N/OFQ), nocistatin, and prepro-N/OFQ 160-187 (C-peptide) are all derived from the same precursor protein. We examine the pharmacological mechanisms of nocistatin- and C-peptide-induced pronociceptive responses in a novel algogenic-induced nociceptive flexion test in mice. The intraplantar (i.pl.) injection of nocistatin- and C-peptide induced pronociceptive responses in ...
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A new biological active hexapeptide of C-terminal of nocistatin, contains Glu-Gln-Lys-Gln-Leu-Gln sequence was synthesized according to solid phase peptide synthesis on the surface of 2-chloro tritylchloride resin and using fmoc-protected amino acids in the presence of TBTU (O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyl uranium tetrafluoroborate) as a coupling reagent. Then, amidation of the C-te...
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